InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEBOX

Summary

InnateDB Gene

IDBG-36519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEBOX

Gene Name

SEBOX homeobox

Synonyms

V75; VN; VNT

Species

Homo sapiens

Ensembl Gene

ENSG00000109072

Encoded Proteins

IDBP-373428

SEBOX homeobox

IDBP-587003

SEBOX homeobox

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Homeodomain proteins, such as SEBOX, play a key role in coordinating gene expression during development (Cinquanta et al., 2000 [PubMed 10922053]).[supplied by OMIM, Mar 2008]
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28367276-28373091

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000438614	ENSP00000395142
ENST00000536498	ENSP00000444503

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.

Experimentally validated
Total	87 [view]
Protein-Protein	82 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0030247	polysaccharide binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010951	negative regulation of endopeptidase activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030195	negative regulation of blood coagulation
GO:0030198	extracellular matrix organization
GO:0030449	regulation of complement activation
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032092	positive regulation of protein binding
GO:0033627	cell adhesion mediated by integrin
GO:0045087	innate immune response
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0061302	smooth muscle cell-matrix adhesion
GO:0090303	positive regulation of wound healing

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0071062	alphav-beta3 integrin-vitronectin complex
GO:0072562	blood microparticle