Version 5.4
Homo sapiens Gene: BST2
Summary
InnateDB Gene IDBG-36619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BST2
Gene Name bone marrow stromal cell antigen 2
Synonyms CD317; TETHERIN
Species Homo sapiens
Ensembl Gene ENSG00000130303
Encoded Proteins
IDBP-36621
bone marrow stromal cell antigen 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19564354
BST2 directly binds to purified LILRA4 (ILT7) protein, initiates signalling via the ILT7-FcepsilonRIgamma complex, and strongly inhibits production of IFN and pro-inflammatory cytokines in plamsmacytoid dendritic cells
PMID 20702620
BST2 (CD317) is a broadly acting and conserved mediator of innate control of retroviral infection and pathogenesis that restricts the release of retroviruses and lentiviruses in rodents by limiting replication of HIV-1 and MLV.
PMID 21734563
BST2 is an innate intracellular HIV restriction factor that is upregulated by type I interferons.
PMID 22072710
BST2 is a broad spectrum effector of the innate immune response to viral infection. BST2 is antagonized by the human immunodeficiency virus (HIV) Vpu protein to evade innate immune system detection.
PMID 24733916
HIV-1 viral protein U, Vpu, protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity as a function of its ability to counteract BST2 (tetherin).
Entrez Gene
Summary Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17402939-17405648
Strand Reverse strand
Band p13.11
Transcripts
ENST00000252593 ENSP00000252593
ENST00000533098
ENST00000527220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002737 negative regulation of plasmacytoid dendritic cell cytokine production
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0009615 response to virus
GO:0010951 negative regulation of endopeptidase activity
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0032956 regulation of actin cytoskeleton organization
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0042113 B cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:1901253 negative regulation of intracellular transport of viral material
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q10589
TrEMBL A0A024R7H5
UniProt Splice Variant
Entrez Gene 684
UniGene
RefSeq NM_004335
HUGO HGNC:1119
OMIM 600534
CCDS CCDS12358
HPRD
IMGT
EMBL AC010319 AK223124 AK291099 BC033873 CH471106 D28137
GenPept AAH33873 BAA05679 BAD96844 BAF83788 EAW84602 EAW84603
RNA Seq Atlas 684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca