Homo sapiens Gene: BST2
Summary
InnateDB Gene IDBG-36619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BST2
Gene Name bone marrow stromal cell antigen 2
Synonyms CD317; TETHERIN;
Species Homo sapiens
Ensembl Gene ENSG00000130303
Encoded Proteins
bone marrow stromal cell antigen 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
BST2 directly binds to purified LILRA4 (ILT7) protein, initiates signalling via the ILT7-FcepsilonRIgamma complex, and strongly inhibits production of IFN and pro-inflammatory cytokines in plamsmacytoid dendritic cells
BST2 (CD317) is a broadly acting and conserved mediator of innate control of retroviral infection and pathogenesis that restricts the release of retroviruses and lentiviruses in rodents by limiting replication of HIV-1 and MLV.
BST2 is an innate intracellular HIV restriction factor that is upregulated by type I interferons.
BST2 is a broad spectrum effector of the innate immune response to viral infection. BST2 is antagonized by the human immunodeficiency virus (HIV) Vpu protein to evade innate immune system detection.
HIV-1 viral protein U, Vpu, protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity as a function of its ability to counteract BST2 (tetherin).
Entrez Gene
Summary Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17402939-17405648
Strand Reverse strand
Band p13.11
Transcripts
ENST00000252593 ENSP00000252593
ENST00000533098
ENST00000527220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002737 negative regulation of plasmacytoid dendritic cell cytokine production
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0009615 response to virus
GO:0010951 negative regulation of endopeptidase activity
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0032956 regulation of actin cytoskeleton organization
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0042113 B cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:1901253 negative regulation of intracellular transport of viral material
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004335
HUGO
OMIM
CCDS CCDS12358
HPRD 02759
IMGT
EMBL
GenPept
RNA Seq Atlas