|Homo sapiens Gene: BST2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||bone marrow stromal cell antigen 2|
bone marrow stromal cell antigen 2
|Useful resources||Stemformatics EHFPI ImmGen|
BST2 directly binds to purified LILRA4 (ILT7) protein, initiates signalling via the ILT7-FcepsilonRIgamma complex, and strongly inhibits production of IFN and pro-inflammatory cytokines in plamsmacytoid dendritic cells
BST2 (CD317) is a broadly acting and conserved mediator of innate control of retroviral infection and pathogenesis that restricts the release of retroviruses and lentiviruses in rodents by limiting replication of HIV-1 and MLV.
BST2 is an innate intracellular HIV restriction factor that is upregulated by type I interferons.
BST2 is a broad spectrum effector of the innate immune response to viral infection. BST2 is antagonized by the human immunodeficiency virus (HIV) Vpu protein to evade innate immune system detection.
HIV-1 viral protein U, Vpu, protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity as a function of its ability to counteract BST2 (tetherin).
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 19:17402939-17405648|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
|UniProt Splice Variant|
|RNA Seq Atlas|