Homo sapiens Gene: STARD4
Summary
InnateDB Gene IDBG-36758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STARD4
Gene Name StAR-related lipid transfer (START) domain containing 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164211
Encoded Proteins
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
StAR-related lipid transfer (START) domain containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:111496033-111512590
Strand Reverse strand
Band q22.1
Transcripts
ENST00000296632 ENSP00000296632
ENST00000455172 ENSP00000407063
ENST00000512160 ENSP00000426148
ENST00000511137 ENSP00000425014
ENST00000502931
ENST00000505803 ENSP00000427478
ENST00000502322 ENSP00000427639
ENST00000509887 ENSP00000425308
ENST00000511569
ENST00000511436
ENST00000510346
ENST00000508215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0006869 lipid transport
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Metabolism of steroid hormones and vitamin D pathway
Metabolism pathway
Pregnenolone biosynthesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595655 Hs.639702 Hs.732430 Hs.93842
RefSeq NM_139164 XM_005271881 XM_005271884
HUGO
OMIM
CCDS CCDS4104
HPRD 06133
IMGT
EMBL
GenPept
RNA Seq Atlas