Version 5.4
| Homo sapiens Gene: PCBP2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-36771.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | PCBP2 | ||||||||||||||||||||||
| Gene Name | poly(rC) binding protein 2 | ||||||||||||||||||||||
| Synonyms | hnRNP-E2; HNRNPE2; HNRPE2 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000197111 | ||||||||||||||||||||||
| Encoded Proteins |
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
poly(rC) binding protein 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
PCBP2 is a negative regulator in MAVS-mediated antiviral signalling that recruits the HECT domain-containing E3 ligase ITCH (AIP4) to polyubiquitinate and degrade MAVS.
PCBP2 synergizes with PCBP1 in MAVS inhibition but PCBP2 shows low basal expression with rapid induction after infection while PCBP1 is stably and abundantly expressed.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Pcbp2 synergizes with Pcbp1 in Mavs inhibition but Pcbp2 shows low basal expression with rapid induction after infection while Pcbp1 is stably and abundantly expressed. (Demonstrated in human)
[Mus musculus] Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5\'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 12:53452102-53481162 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q13.13 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
mRNA Splicing - Major Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
Innate Immune System pathway
Immune System pathway
mRNA Splicing pathway
Gene Expression pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | Q15366 | ||||||||||||||||||||||
| TrEMBL | F8VTZ0 F8W0G4 H3BSP4 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 5094 | ||||||||||||||||||||||
| UniGene | Hs.593270 Hs.613168 Hs.682702 Hs.724359 | ||||||||||||||||||||||
| RefSeq | NM_001128912 NM_001098620 NM_001128911 NM_001128913 NM_001128914 NM_005016 NM_031989 | ||||||||||||||||||||||
| HUGO | HGNC:8648 | ||||||||||||||||||||||
| OMIM | 601210 | ||||||||||||||||||||||
| CCDS | CCDS55830 CCDS44900 CCDS44901 CCDS44902 CCDS44903 CCDS44904 CCDS8859 | ||||||||||||||||||||||
| HPRD | 03129 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AB188306 AB208825 AC023509 AC068889 AK292141 BC001155 BC071942 BC107688 CH471054 X78136 | ||||||||||||||||||||||
| GenPept | AAH01155 AAH71942 AAI07689 BAD36897 BAD92062 BAF84830 CAA55015 EAW96706 EAW96707 EAW96709 EAW96711 | ||||||||||||||||||||||
| RNA Seq Atlas | 5094 | ||||||||||||||||||||||