Version 5.4
Homo sapiens Gene: IFRD1
Summary
InnateDB Gene IDBG-36786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFRD1
Gene Name interferon-related developmental regulator 1
Synonyms PC4; TIS7
Species Homo sapiens
Ensembl Gene ENSG00000006652
Encoded Proteins
IDBP-36788
interferon-related developmental regulator 1
IDBP-294720
interferon-related developmental regulator 1
IDBP-385361
interferon-related developmental regulator 1
IDBP-385369
interferon-related developmental regulator 1
IDBP-385372
interferon-related developmental regulator 1
IDBP-385373
interferon-related developmental regulator 1
IDBP-385375
interferon-related developmental regulator 1
IDBP-385381
interferon-related developmental regulator 1
IDBP-385382
interferon-related developmental regulator 1
IDBP-604088
interferon-related developmental regulator 1
IDBP-604089
interferon-related developmental regulator 1
IDBP-604090
interferon-related developmental regulator 1
IDBP-810783
interferon-related developmental regulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26055519
Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
Entrez Gene
Summary This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:112422968-112481017
Strand Forward strand
Band q31.1
Transcripts
ENST00000005558 ENSP00000005558
ENST00000403825 ENSP00000384477
ENST00000432734 ENSP00000391379
ENST00000443101 ENSP00000397592
ENST00000445335 ENSP00000402453
ENST00000417662 ENSP00000413893
ENST00000429071 ENSP00000397314
ENST00000440625 ENSP00000402177
ENST00000421296 ENSP00000403203
ENST00000476927 ENSP00000437250
ENST00000466459
ENST00000486688
ENST00000489994
ENST00000470441
ENST00000462155 ENSP00000435635
ENST00000535603 ENSP00000439188
ENST00000621379 ENSP00000483255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007518 myoblast cell fate determination
GO:0007527 adult somatic muscle development
GO:0042692 muscle cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001627
View Gene Order
ENSBTAG00000010549
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.702661 Hs.709100 Hs.729518 Hs.7879
RefSeq NM_001007245 NM_001197079 NM_001197080 NM_001550
HUGO
OMIM
CCDS CCDS34736 CCDS56504
HPRD 04612
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca