Version 5.4
Homo sapiens Gene: AGRP
Summary
InnateDB Gene IDBG-36875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGRP
Gene Name agouti related protein homolog (mouse)
Synonyms AGRT; ART; ASIP2
Species Homo sapiens
Ensembl Gene ENSG00000159723
Encoded Proteins
IDBP-36877
agouti related protein homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67482571-67483813
Strand Reverse strand
Band q22.1
Transcripts
ENST00000290953 ENSP00000290953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005184 neuropeptide hormone activity
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
GO:0008343 adult feeding behavior
GO:0009648 photoperiodism
GO:0009755 hormone-mediated signaling pathway
GO:0032868 response to insulin
GO:0042755 eating behavior
GO:0060135 maternal process involved in female pregnancy
GO:0060259 regulation of feeding behavior
GO:2000253 positive regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005705
View Gene Order
ENSBTAG00000014556
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04920
Adipocytokine signaling pathway pathway
INOH
PID NCI
syndecan_3_pathway
Syndecan-3-mediated signaling events
Cross-References
SwissProt O00253
TrEMBL C6SUN5
UniProt Splice Variant
Entrez Gene 181
UniGene
RefSeq NM_001138
HUGO HGNC:330
OMIM 602311
CCDS CCDS10839
HPRD
IMGT
EMBL AF281309 AF314194 BC110443 BK006637 CH471092 DQ374394 U88063 U89485
GenPept AAB52240 AAB68621 AAI10444 AAK96256 AAL09457 ABC88473 DAA06531 EAW83137
RNA Seq Atlas 181

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca