InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALDOC

Summary

InnateDB Gene

IDBG-36924.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDOC

Gene Name

aldolase C, fructose-bisphosphate

Synonyms

ALDC

Species

Homo sapiens

Ensembl Gene

ENSG00000109107

Encoded Proteins

IDBP-36926

aldolase C, fructose-bisphosphate

IDBP-239773

aldolase C, fructose-bisphosphate

IDBP-239775

aldolase C, fructose-bisphosphate

IDBP-373625

aldolase C, fructose-bisphosphate

IDBP-758388

IDBP-760399

IDBP-758037

IDBP-761154

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28573115-28577264

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000226253	ENSP00000226253
ENST00000395321	ENSP00000378731
ENST00000395319	ENSP00000378729
ENST00000435638	ENSP00000398976
ENST00000460201	ENSP00000463174
ENST00000578590	ENSP00000463118
ENST00000584086	ENSP00000462674
ENST00000582381
ENST00000581807	ENSP00000465623

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006915	apoptotic process
GO:0007568	aging
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0030855	epithelial cell differentiation
GO:0031100	organ regeneration
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization
GO:0051290	protein heterotetramerization