Homo sapiens Gene: NEDD8
Summary
InnateDB Gene IDBG-3700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEDD8
Gene Name neural precursor cell expressed, developmentally down-regulated 8
Synonyms NEDD-8;
Species Homo sapiens
Ensembl Gene ENSG00000129559
Encoded Proteins
neural precursor cell expressed, developmentally down-regulated 8
neural precursor cell expressed, developmentally down-regulated 8
neural precursor cell expressed, developmentally down-regulated 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24216852-24232454
Strand Reverse strand
Band q12
Transcripts
ENST00000250495 ENSP00000250495
ENST00000396828 ENSP00000380040
ENST00000527046
ENST00000531430
ENST00000560427
ENST00000526430
ENST00000524927 ENSP00000448192
ENST00000533242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 793 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 793 [view]
Protein-Protein 791 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008104 protein localization
GO:0009653 anatomical structure morphogenesis
GO:0014070 response to organic cyclic compound
GO:0045116 protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID BIOCARTA
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.531064 Hs.571861 Hs.666696
RefSeq NM_006156
HUGO
OMIM
CCDS CCDS9621
HPRD 04412
IMGT
EMBL
GenPept
RNA Seq Atlas