Homo sapiens Gene: JAK3
Summary
InnateDB Gene IDBG-37201.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JAK3
Gene Name Janus kinase 3
Synonyms JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK;
Species Homo sapiens
Ensembl Gene ENSG00000105639
Encoded Proteins
Janus kinase 3
Janus kinase 3
Janus kinase 3
Janus kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
JAK3 is a primary response gene for IL6 in macrophage differentiation and ectopic overexpression of JAK3 accelerates monocytic differentiation of normal mouse bone marrow cells stimulated with cytokines.
JAK3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Jak3 inhibition is sufficient to counteract lung injury and protect immunocytes from hypercytokinemia following challenge with avian influenza H5N1 hemagglutinin.
Entrez Gene
Summary The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17824780-17848071
Strand Reverse strand
Band p13.11
Transcripts
ENST00000458235 ENSP00000391676
ENST00000527031
ENST00000527670 ENSP00000432511
ENST00000534444 ENSP00000436421
ENST00000526008
ENST00000528705
ENST00000528293
ENST00000613342 ENSP00000481954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
Biological Process
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007262 STAT protein import into nucleus
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035771 interleukin-4-mediated signaling pathway
GO:0043029 T cell homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045221 negative regulation of FasL biosynthetic process
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050868 negative regulation of T cell activation
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
TCR pathway
IL2 pathway
IL4 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
INOH
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il 6 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Stat3 signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
CD40/CD40L signaling
IL2-mediated signaling events
Signaling events mediated by TCPTP
IL4-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt P52333
TrEMBL Q6LD09
UniProt Splice Variant
Entrez Gene 3718
UniGene Hs.515247 Hs.622989
RefSeq NM_000215 XM_005259896 XM_006722745
HUGO HGNC:6193
OMIM 600173
CCDS CCDS12366
HPRD 02547
IMGT
EMBL AC007201 AF513860 BC028068 CH471106 U08340 U09607 U31601 U31602 U57096 U70065
GenPept AAA17743 AAA19626 AAC50226 AAC50227 AAC50542 AAC50950 AAD22741 AAH28068 AAM44860 EAW84639
RNA Seq Atlas 3718