Version 5.4
Homo sapiens Gene: SLC5A6
Summary
InnateDB Gene IDBG-37411.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A6
Gene Name solute carrier family 5 (sodium-dependent vitamin transporter), member 6
Synonyms SMVT
Species Homo sapiens
Ensembl Gene ENSG00000138074
Encoded Proteins
IDBP-37415
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-294574
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-294572
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368821
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368824
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368829
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368835
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368839
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368841
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368845
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
IDBP-368848
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27199587-27212958
Strand Reverse strand
Band p23.3
Transcripts
ENST00000310574 ENSP00000310208
ENST00000408041 ENSP00000384853
ENST00000401463 ENSP00000384265
ENST00000445802 ENSP00000411361
ENST00000412471 ENSP00000403851
ENST00000432106 ENSP00000411536
ENST00000426119 ENSP00000401347
ENST00000414408 ENSP00000404032
ENST00000428518 ENSP00000402903
ENST00000430186 ENSP00000399299
ENST00000442731 ENSP00000412115
ENST00000461757
ENST00000488743
ENST00000461319
ENST00000481751
ENST00000492069
ENST00000476319
ENST00000464538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008523 sodium-dependent multivitamin transmembrane transporter activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006768 biotin metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0015878 biotin transport
GO:0015887 pantothenate transmembrane transport
GO:0015939 pantothenate metabolic process
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006641
View Gene Order
ENSBTAG00000006832
Not yet available
Pathways
NETPATH
REACTOME
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_11153
Biotin transport and metabolism pathway
REACT_11172
Vitamin B5 (pantothenate) metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435735
RefSeq NM_021095 XM_006712128 XM_006712129 XM_006712130
HUGO
OMIM
CCDS CCDS1740
HPRD 04934
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca