Version 5.4
Homo sapiens Gene: SMUG1
Summary
InnateDB Gene IDBG-37516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMUG1
Gene Name single-strand-selective monofunctional uracil-DNA glycosylase 1
Synonyms FDG; HMUDG; UNG3
Species Homo sapiens
Ensembl Gene ENSG00000123415
Encoded Proteins
IDBP-37518
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-37520
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-295544
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485507
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485509
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485510
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485511
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485512
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485513
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485514
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485515
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485516
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485518
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485519
single-strand-selective monofunctional uracil-DNA glycosylase 1
IDBP-485520
single-strand-selective monofunctional uracil-DNA glycosylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:54164745-54188994
Strand Reverse strand
Band q13.13
Transcripts
ENST00000337581 ENSP00000338606
ENST00000243112 ENSP00000243112
ENST00000401977 ENSP00000384828
ENST00000509864 ENSP00000426440
ENST00000514685 ENSP00000421139
ENST00000506595 ENSP00000421206
ENST00000511854
ENST00000505128 ENSP00000421894
ENST00000508394 ENSP00000424191
ENST00000513838 ENSP00000423629
ENST00000505662
ENST00000514196 ENSP00000425974
ENST00000511522
ENST00000504338 ENSP00000423083
ENST00000509078
ENST00000507904 ENSP00000423457
ENST00000503447
ENST00000504797 ENSP00000421790
ENST00000506169 ENSP00000427547
ENST00000503306 ENSP00000425426
ENST00000505597
ENST00000503231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0017065 single-strand selective uracil DNA N-glycosylase activity
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0045008 depyrimidination
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036061
View Gene Order
ENSBTAG00000021974
Not yet available
Pathways
NETPATH
REACTOME
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2156
Cleavage of the damaged pyrimidine pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_702
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1405
Depyrimidination pathway
REACT_1104
Base Excision Repair pathway
REACT_804
Base-Excision Repair, AP Site Formation pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.613709 Hs.731659
RefSeq NM_001243787 NM_001243788 NM_001243789 NM_001243790 NM_001243791 NM_014311 XM_006719321 XM_006719322
HUGO
OMIM
CCDS CCDS58239 CCDS8874
HPRD 06376
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca