InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CBX5

Summary

InnateDB Gene

IDBG-37553.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX5

Gene Name

chromobox homolog 5

Synonyms

HEL25; HP1; HP1A

Species

Homo sapiens

Ensembl Gene

ENSG00000094916

Encoded Proteins

IDBP-37555

chromobox homolog 5

IDBP-376658

chromobox homolog 5

IDBP-593433

chromobox homolog 5

IDBP-603730

chromobox homolog 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:54230940-54280133

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000209875	ENSP00000209875
ENST00000439541	ENSP00000401009
ENST00000547872
ENST00000550411	ENSP00000449207
ENST00000552562	ENSP00000450190
ENST00000618078

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 230 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	230 [view]
Protein-Protein	223 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0035064	methylated histone binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0007596	blood coagulation
GO:0016032	viral process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000776	kinetochore
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005720	nuclear heterochromatin
GO:0005730	nucleolus
GO:0010369	chromocenter
GO:0016605	PML body
GO:0017053	transcriptional repressor complex
GO:0031618	nuclear centromeric heterochromatin
GO:0035097	histone methyltransferase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009575

View Gene Order

ENSBTAG00000006246

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

e2f_pathway

E2F transcription factor network

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

P45973

TrEMBL

F8VNY3 V9HWG0

UniProt Splice Variant

Entrez Gene

23468

UniGene

Hs.349283 Hs.623361

RefSeq

NM_001127322 NM_001127321 NM_012117

HUGO

HGNC:1555

OMIM

604478

CCDS

CCDS8875

HPRD

05131

IMGT

EMBL

AC078778 AK313506 BC006821 CH471054 EU794599 L07515 S62077 U26311

GenPept

AAA72327 AAB26994 AAC50553 AAH06821 ACJ13653 BAG36286 EAW96759 EAW96760

RNA Seq Atlas

23468