Version 5.4
Homo sapiens Gene: TRAF4
Summary
InnateDB Gene IDBG-37645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF4
Gene Name TNF receptor-associated factor 4
Synonyms CART1; MLN62; RNF83
Species Homo sapiens
Ensembl Gene ENSG00000076604
Encoded Proteins
IDBP-37647
TNF receptor-associated factor 4
IDBP-37649
TNF receptor-associated factor 4
IDBP-373997
TNF receptor-associated factor 4
IDBP-374001
TNF receptor-associated factor 4
IDBP-584051
TNF receptor-associated factor 4
IDBP-764730
IDBP-763970
IDBP-762836
IDBP-762042
IDBP-759903
IDBP-810993
TNF receptor-associated factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28743984-28750958
Strand Forward strand
Band q11.2
Transcripts
ENST00000262395 ENSP00000262395
ENST00000262396 ENSP00000262396
ENST00000394925
ENST00000454852 ENSP00000396602
ENST00000422344 ENSP00000415789
ENST00000444415 ENSP00000438154
ENST00000478021 ENSP00000464097
ENST00000461195
ENST00000498540
ENST00000475329 ENSP00000464583
ENST00000473421 ENSP00000468107
ENST00000469529
ENST00000584944 ENSP00000465164
ENST00000578917
ENST00000580073
ENST00000586813 ENSP00000466306
ENST00000618771 ENSP00000481248
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 90 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0046872 metal ion binding
GO:0050699 WW domain binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007585 respiratory gaseous exchange
GO:0016567 protein ubiquitination
GO:0030323 respiratory tube development
GO:0042981 regulation of apoptotic process
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0090073 positive regulation of protein homodimerization activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017386
View Gene Order
ENSBTAG00000038990
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004295
HUGO
OMIM
CCDS CCDS11243
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca