InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KLF5

Summary

InnateDB Gene

IDBG-37932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF5

Gene Name

Kruppel-like factor 5 (intestinal)

Synonyms

BTEB2; CKLF; IKLF

Species

Homo sapiens

Ensembl Gene

ENSG00000102554

Encoded Proteins

IDBP-37934

Kruppel-like factor 5 (intestinal)

IDBP-589046

Kruppel-like factor 5 (intestinal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:73054976-73077542

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000377687	ENSP00000366915
ENST00000477333
ENST00000476859
ENST00000464404
ENST00000539231	ENSP00000440407

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	41 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0030033	microvillus assembly
GO:0032534	regulation of microvillus assembly
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060576	intestinal epithelial cell development
GO:0071407	cellular response to organic cyclic compound
GO:1901653	cellular response to peptide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005148

View Gene Order

ENSBTAG00000002129

Not yet available

Pathways

NETPATH

REACTOME

REACT_27161

Transcriptional regulation of white adipocyte differentiation pathway

REACT_111045

Developmental Biology pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.508234 Hs.604315 Hs.621693

RefSeq

NM_001286818 NM_001730 XM_005266509 XM_006719862

HUGO

OMIM

CCDS

CCDS66562 CCDS9448

HPRD

04212

IMGT

EMBL

GenPept

RNA Seq Atlas