Version 5.4
Homo sapiens Gene: TRIM54
Summary
InnateDB Gene IDBG-38087.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM54
Gene Name tripartite motif containing 54
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138100
Encoded Proteins
IDBP-38091
tripartite motif containing 54
IDBP-38093
tripartite motif containing 54
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27282392-27307439
Strand Forward strand
Band p23.3
Transcripts
ENST00000380075 ENSP00000369415
ENST00000296098 ENSP00000296098
ENST00000488321
ENST00000485306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007017 microtubule-based process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0046417 chorismate metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062077
View Gene Order
ENSBTAG00000018267
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516036
RefSeq NM_032546 NM_187841 XM_006712053
HUGO
OMIM
CCDS CCDS1745 CCDS1746
HPRD 05928
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca