Version 5.4
Homo sapiens Gene: DCD
Summary
InnateDB Gene IDBG-38275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCD
Gene Name dermcidin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161634
Encoded Proteins
IDBP-38277
dermcidin
IDBP-377004
dermcidin
IDBP-583651
dermcidin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19014393
Activates normal human keratinocytes and display in vitro microbicidal activities against bacteria and viruses
PMID 22262861
DCD encodes the anionic amphiphilic peptide DCD-1L that interacts with negatively charged bacterial phospholipids to form ion channels in the bacterial membrane.
Entrez Gene
Summary This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:54644591-54648493
Strand Reverse strand
Band q13.2
Transcripts
ENST00000293371 ENSP00000293371
ENST00000456047 ENSP00000406773
ENST00000546807 ENSP00000450415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006508 proteolysis
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001300854 NM_053283 XM_005268627
HUGO
OMIM
CCDS CCDS73478 CCDS8884
HPRD 07363
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca