Homo sapiens Gene: NDUFC1
Summary
InnateDB Gene IDBG-38367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFC1
Gene Name NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
Synonyms KFYI;
Species Homo sapiens
Ensembl Gene ENSG00000109390
Encoded Proteins
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:139266880-139302551
Strand Reverse strand
Band q31.1
Transcripts
ENST00000394228 ENSP00000377775
ENST00000394225
ENST00000394223 ENSP00000377770
ENST00000503997 ENSP00000425882
ENST00000505036 ENSP00000421195
ENST00000503453
ENST00000513022
ENST00000507764
ENST00000539387 ENSP00000439882
ENST00000544855 ENSP00000441126
ENST00000539002 ENSP00000440133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43677
TrEMBL Q4W5J3
UniProt Splice Variant
Entrez Gene 4717
UniGene
RefSeq NM_001184986 NM_001184987 NM_001184988 NM_001184989 NM_001184990 NM_001184991 NM_002494
HUGO HGNC:7705
OMIM 603844
CCDS CCDS3746
HPRD
IMGT
EMBL AC097376 AF047184 AF047435 AK291147 BC101798 BC107682 BC112061 CH471056
GenPept AAC04269 AAC39886 AAI01799 AAI07683 AAI12062 AAY40949 BAF83836 EAX05121
RNA Seq Atlas 4717