InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDH1

Summary

InnateDB Gene

IDBG-38622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH1

Gene Name

cadherin 1, type 1, E-cadherin (epithelial)

Synonyms

Arc-1; CD324; CDHE; ECAD; LCAM; UVO

Species

Homo sapiens

Ensembl Gene

ENSG00000039068

Encoded Proteins

IDBP-38624

cadherin 1, type 1, E-cadherin (epithelial)

IDBP-379655

cadherin 1, type 1, E-cadherin (epithelial)

IDBP-753734

IDBP-752238

IDBP-752722

IDBP-809467

cadherin 1, type 1, E-cadherin (epithelial)

IDBP-809469

cadherin 1, type 1, E-cadherin (epithelial)

IDBP-809471

cadherin 1, type 1, E-cadherin (epithelial)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:68737225-68835548

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000261769	ENSP00000261769
ENST00000422392	ENSP00000414946
ENST00000567320
ENST00000561751	ENSP00000463170
ENST00000564676
ENST00000566510	ENSP00000458139
ENST00000565810
ENST00000562836
ENST00000564745
ENST00000566612	ENSP00000454782
ENST00000562118
ENST00000611625	ENSP00000481063
ENST00000612417	ENSP00000478360
ENST00000621016	ENSP00000480664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 189 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	189 [view]
Protein-Protein	165 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0030506	ankyrin binding
GO:0032794	GTPase activating protein binding
GO:0045295	gamma-catenin binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0003382	epithelial cell morphogenesis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007156	homophilic cell adhesion
GO:0007416	synapse assembly
GO:0007605	sensory perception of sound
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0016337	single organismal cell-cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0019538	protein metabolic process
GO:0021983	pituitary gland development
GO:0022408	negative regulation of cell-cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0031175	neuron projection development
GO:0032880	regulation of protein localization
GO:0033561	regulation of water loss via skin
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0042493	response to drug
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045216	cell-cell junction organization
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050776	regulation of immune response
GO:0051260	protein homooligomerization
GO:0060576	intestinal epithelial cell development
GO:0060662	salivary gland cavitation
GO:0060693	regulation of branching involved in salivary gland morphogenesis
GO:0070830	tight junction assembly
GO:0071230	cellular response to amino acid stimulus
GO:0071285	cellular response to lithium ion
GO:0071681	cellular response to indole-3-methanol
GO:0072659	protein localization to plasma membrane
GO:0090002	establishment of protein localization to plasma membrane
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090102	cochlea development
GO:2000008	regulation of protein localization to cell surface
GO:2001222	regulation of neuron migration

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion
GO:0009898	cytoplasmic side of plasma membrane
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016235	aggresome
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0016342	catenin complex
GO:0030054	cell junction
GO:0030424	axon
GO:0033268	node of Ranvier
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043296	apical junction complex
GO:0043679	axon terminus
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery