Homo sapiens Gene: CDH1
Summary
InnateDB Gene IDBG-38622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH1
Gene Name cadherin 1, type 1, E-cadherin (epithelial)
Synonyms Arc-1; CD324; CDHE; ECAD; LCAM; UVO;
Species Homo sapiens
Ensembl Gene ENSG00000039068
Encoded Proteins
cadherin 1, type 1, E-cadherin (epithelial)
cadherin 1, type 1, E-cadherin (epithelial)
cadherin 1, type 1, E-cadherin (epithelial)
cadherin 1, type 1, E-cadherin (epithelial)
cadherin 1, type 1, E-cadherin (epithelial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68737225-68835548
Strand Forward strand
Band q22.1
Transcripts
ENST00000261769 ENSP00000261769
ENST00000422392 ENSP00000414946
ENST00000567320
ENST00000561751 ENSP00000463170
ENST00000564676
ENST00000566510 ENSP00000458139
ENST00000565810
ENST00000562836
ENST00000564745
ENST00000566612 ENSP00000454782
ENST00000562118
ENST00000611625 ENSP00000481063
ENST00000612417 ENSP00000478360
ENST00000621016 ENSP00000480664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 189 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 189 [view]
Protein-Protein 165 [view]
Protein-DNA 24 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030506 ankyrin binding
GO:0032794 GTPase activating protein binding
GO:0045295 gamma-catenin binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0003382 epithelial cell morphogenesis
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007156 homophilic cell adhesion
GO:0007416 synapse assembly
GO:0007605 sensory perception of sound
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0016337 single organismal cell-cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
GO:0019538 protein metabolic process
GO:0021983 pituitary gland development
GO:0022408 negative regulation of cell-cell adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0031175 neuron projection development
GO:0032880 regulation of protein localization
GO:0033561 regulation of water loss via skin
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0042493 response to drug
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045216 cell-cell junction organization
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050776 regulation of immune response
GO:0051260 protein homooligomerization
GO:0060576 intestinal epithelial cell development
GO:0060662 salivary gland cavitation
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0070830 tight junction assembly
GO:0071230 cellular response to amino acid stimulus
GO:0071285 cellular response to lithium ion
GO:0071681 cellular response to indole-3-methanol
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090102 cochlea development
GO:2000008 regulation of protein localization to cell surface
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016235 aggresome
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030054 cell junction
GO:0030424 axon
GO:0033268 node of Ranvier
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043296 apical junction complex
GO:0043679 axon terminus
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
Wnt pathway
REACTOME
Apoptotic execution phase pathway
Cell-Cell communication pathway
Extracellular matrix organization pathway
Cell junction organization pathway
Degradation of the extracellular matrix pathway
Apoptosis pathway
Apoptotic cleavage of cell adhesion proteins pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Apoptotic cleavage of cellular proteins pathway
Integrin cell surface interactions pathway
Immune System pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Adherens junction pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Pathways in cancer pathway
Endometrial cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
INOH
PID BIOCARTA
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
Cell to cell adhesion signaling [Biocarta view]
Tgf beta signaling pathway [Biocarta view]
Sumoylation as a mechanism to modulate ctbp-dependent gene responses [Biocarta view]
PID NCI
E-cadherin signaling events
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Nectin adhesion pathway
a6b1 and a6b4 Integrin signaling
Regulation of nuclear beta catenin signaling and target gene transcription
RAC1 signaling pathway
FGF signaling pathway
CDC42 signaling events
AlphaE beta7 integrin cell surface interactions
Stabilization and expansion of the E-cadherin adherens junction
E-cadherin signaling in keratinocytes
Arf6 trafficking events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL H3BVI7
UniProt Splice Variant
Entrez Gene 999
UniGene Hs.461086 Hs.708913
RefSeq NM_004360
HUGO HGNC:1748
OMIM 192090
CCDS CCDS10869
HPRD 01885
IMGT
EMBL AC099314
GenPept
RNA Seq Atlas 999