Homo sapiens Gene: FBXO3
Summary
InnateDB Gene IDBG-38875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO3
Gene Name F-box protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110429
Encoded Proteins
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
F-box protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:33740939-33774543
Strand Reverse strand
Band p13
Transcripts
ENST00000265651 ENSP00000265651
ENST00000448981 ENSP00000408836
ENST00000526785 ENSP00000435680
ENST00000530013
ENST00000530401 ENSP00000433781
ENST00000531080 ENSP00000435165
ENST00000532057 ENSP00000434001
ENST00000534136 ENSP00000431745
ENST00000527772
ENST00000532927 ENSP00000434099
ENST00000529137 ENSP00000431502
ENST00000533103
ENST00000526952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UK99
TrEMBL B4E3U2 E9PJM3 E9PL46 G3V1E0 Q49AF1
UniProt Splice Variant
Entrez Gene 26273
UniGene Hs.406787 Hs.732398 Hs.733093
RefSeq NM_012175 NM_033406 XM_005252851
HUGO HGNC:13582
OMIM 609089
CCDS CCDS44566 CCDS7887
HPRD
IMGT
EMBL AC113192 AF176702 AK001943 AK128454 AK304866 AK316286 AL049629 AL136625 BC039291 BC046110 CH471064
GenPept AAF03702 AAH39291 AAH46110 BAA91991 BAG54678 BAG65604 BAH14657 CAB66560 EAW68186 EAW68188 EAW68189 EAW68191
RNA Seq Atlas 26273