Homo sapiens Gene: LMO2
Summary
InnateDB Gene IDBG-38928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMO2
Gene Name LIM domain only 2 (rhombotin-like 1)
Synonyms RBTN2; RBTNL1; RHOM2; TTG2;
Species Homo sapiens
Ensembl Gene ENSG00000135363
Encoded Proteins
LIM domain only 2 (rhombotin-like 1)
LIM domain only 2 (rhombotin-like 1)
LIM domain only 2 (rhombotin-like 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:33858576-33892289
Strand Reverse strand
Band p13
Transcripts
ENST00000257818 ENSP00000257818
ENST00000395833 ENSP00000379175
ENST00000411482 ENSP00000401967
ENST00000464025
ENST00000465614
ENST00000493667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043425 bHLH transcription factor binding
GO:0048037 cofactor binding
GO:0070888 E-box binding
Biological Process
GO:0007275 multicellular organismal development
GO:0035162 embryonic hemopoiesis
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.34560 Hs.602474
RefSeq NM_001142315 NM_001142316 NM_005574 XM_005252921 XM_006718229
HUGO
OMIM
CCDS CCDS44567 CCDS7888
HPRD 01586
IMGT
EMBL
GenPept
RNA Seq Atlas