InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LMO2

Summary

InnateDB Gene

IDBG-38928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMO2

Gene Name

LIM domain only 2 (rhombotin-like 1)

Synonyms

RBTN2; RBTNL1; RHOM2; TTG2

Species

Homo sapiens

Ensembl Gene

ENSG00000135363

Encoded Proteins

IDBP-38930

LIM domain only 2 (rhombotin-like 1)

IDBP-238749

LIM domain only 2 (rhombotin-like 1)

IDBP-370977

LIM domain only 2 (rhombotin-like 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:33858576-33892289

Strand

Reverse strand

Band

p13

Transcripts

ENST00000257818	ENSP00000257818
ENST00000395833	ENSP00000379175
ENST00000411482	ENSP00000401967
ENST00000464025
ENST00000465614
ENST00000493667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043425	bHLH transcription factor binding
GO:0048037	cofactor binding
GO:0070888	E-box binding

Biological Process

GO:0007275	multicellular organismal development
GO:0035162	embryonic hemopoiesis
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032698

View Gene Order

ENSBTAG00000006951

Not yet available

Cross-References

SwissProt

P25791

TrEMBL

UniProt Splice Variant

Entrez Gene

4005

UniGene

Hs.34560 Hs.602474

RefSeq

NM_001142315 NM_001142316 NM_005574 XM_005252921 XM_006718229

HUGO

HGNC:6642

OMIM

180385

CCDS

CCDS44567 CCDS7888

HPRD

IMGT

EMBL

AF257211 BC034041 BC035607 BC042426 BC073973 X61118

GenPept

AAF98804 AAH34041 AAH35607 AAH42426 AAH73973 CAA43430

RNA Seq Atlas

4005