InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WASL

Summary

InnateDB Gene

IDBG-38956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASL

Gene Name

Wiskott-Aldrich syndrome-like

Synonyms

N-WASP; NWASP

Species

Homo sapiens

Ensembl Gene

ENSG00000106299

Encoded Proteins

IDBP-38958

Wiskott-Aldrich syndrome-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:123681935-123749067

Strand

Reverse strand

Band

q31.32

Transcripts

ENST00000223023

ENSP00000223023

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0006900	membrane budding
GO:0006928	cellular component movement
GO:0007015	actin filament organization
GO:0007067	mitotic nuclear division
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0009617	response to bacterium
GO:0016050	vesicle organization
GO:0030036	actin cytoskeleton organization
GO:0030050	vesicle transport along actin filament
GO:0032880	regulation of protein localization
GO:0034629	cellular protein complex localization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:2000370	positive regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030027	lamellipodium
GO:0030478	actin cap
GO:0030666	endocytic vesicle membrane
GO:0070062	extracellular vesicular exosome