InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOMER3

Summary

InnateDB Gene

IDBG-39136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOMER3

Gene Name

homer homolog 3 (Drosophila)

Synonyms

HOMER-3; VESL3

Species

Homo sapiens

Ensembl Gene

ENSG00000051128

Encoded Proteins

IDBP-39140

homer homolog 3 (Drosophila)

IDBP-245836

homer homolog 3 (Drosophila)

IDBP-376293

homer homolog 3 (Drosophila)

IDBP-584724

homer homolog 3 (Drosophila)

IDBP-595341

homer homolog 3 (Drosophila)

IDBP-763102

IDBP-760101

IDBP-765634

IDBP-762150

IDBP-760974

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18929201-18941261

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000221222	ENSP00000221222
ENST00000392351	ENSP00000376162
ENST00000433218	ENSP00000396154
ENST00000542541	ENSP00000446026
ENST00000539827	ENSP00000439937
ENST00000599097	ENSP00000472800
ENST00000599808
ENST00000595756
ENST00000594794	ENSP00000469800
ENST00000600077	ENSP00000470659
ENST00000596482	ENSP00000472815
ENST00000594439	ENSP00000471835

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006605	protein targeting
GO:0007216	G-protein coupled glutamate receptor signaling pathway

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045178	basal part of cell
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003573

View Gene Order

ENSBTAG00000000813

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9NSC5

TrEMBL

M0QZN1 M0R2T8 M0R2U7

UniProt Splice Variant

Entrez Gene

9454

UniGene

Hs.720208

RefSeq

NM_001145721 XM_006722944 NM_001145722 NM_001145724 NM_004838 XM_006722943

HUGO

HGNC:17514

OMIM

604800

CCDS

CCDS46023 CCDS12391 CCDS46022

HPRD

07270

IMGT

EMBL

AC002985 AF093265 BC012113 Y17573 Y18894 Y18895 Y18896

GenPept

AAB81545 AAC71029 AAH12113 CAB75536 CAB75543 CAB75544 CAB75545

RNA Seq Atlas

9454