InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PUF60

Summary

InnateDB Gene

IDBG-39284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PUF60

Gene Name

poly-U binding splicing factor 60KDa

Synonyms

FIR; RoBPI; SIAHBP1; VRJS

Species

Homo sapiens

Ensembl Gene

ENSG00000179950

Encoded Proteins

IDBP-39286

poly-U binding splicing factor 60KDa

IDBP-39288

poly-U binding splicing factor 60KDa

IDBP-377712

poly-U binding splicing factor 60KDa

IDBP-377714

poly-U binding splicing factor 60KDa

IDBP-596230

poly-U binding splicing factor 60KDa

IDBP-584457

poly-U binding splicing factor 60KDa

IDBP-589599

poly-U binding splicing factor 60KDa

IDBP-584243

poly-U binding splicing factor 60KDa

IDBP-597003

poly-U binding splicing factor 60KDa

IDBP-599668

poly-U binding splicing factor 60KDa

IDBP-587921

poly-U binding splicing factor 60KDa

IDBP-586840

poly-U binding splicing factor 60KDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:143816344-143829859

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000313352	ENSP00000322016
ENST00000349157	ENSP00000322036
ENST00000456095	ENSP00000395417
ENST00000453551	ENSP00000402953
ENST00000526683	ENSP00000434359
ENST00000527197	ENSP00000431960
ENST00000524570
ENST00000532884	ENSP00000432091
ENST00000526459	ENSP00000432610
ENST00000527744	ENSP00000436131
ENST00000531951
ENST00000528320
ENST00000529999	ENSP00000434863
ENST00000528999
ENST00000531897	ENSP00000437309
ENST00000529693
ENST00000533162	ENSP00000433403
ENST00000527584
ENST00000531995
ENST00000532127
ENST00000526151
ENST00000533362

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.

Experimentally validated
Total	113 [view]
Protein-Protein	112 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006915	apoptotic process
GO:0008380	RNA splicing

Cellular Component

GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002524

View Gene Order

ENSBTAG00000037493

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q9UHX1

TrEMBL

UniProt Splice Variant

Entrez Gene

22827

UniGene

Hs.521924

RefSeq

NM_001271097 NM_001136033 NM_001271096 NM_001271098 NM_001271099 NM_001271100 NM_014281 NM_078480

HUGO

HGNC:17042

OMIM

604819

CCDS

CCDS59515 CCDS47933 CCDS47934 CCDS47935 CCDS59514 CCDS59516

HPRD

18051

IMGT

EMBL

AF114818 AF190744 AF217197 AK292373 BC008875 BC009734 BC011265 BC011979 CH471162 CR457143 U51586

GenPept

AAB41656 AAF05605 AAF23589 AAF27522 AAH08875 AAH09734 AAH11265 AAH11979 BAF85062 CAG33424 EAW82187 EAW82189

RNA Seq Atlas

22827