Homo sapiens Gene: PUF60
Summary
InnateDB Gene IDBG-39284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUF60
Gene Name poly-U binding splicing factor 60KDa
Synonyms FIR; RoBPI; SIAHBP1; VRJS;
Species Homo sapiens
Ensembl Gene ENSG00000179950
Encoded Proteins
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
poly-U binding splicing factor 60KDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143816344-143829859
Strand Reverse strand
Band q24.3
Transcripts
ENST00000313352 ENSP00000322016
ENST00000349157 ENSP00000322036
ENST00000456095 ENSP00000395417
ENST00000453551 ENSP00000402953
ENST00000526683 ENSP00000434359
ENST00000527197 ENSP00000431960
ENST00000524570
ENST00000532884 ENSP00000432091
ENST00000526459 ENSP00000432610
ENST00000527744 ENSP00000436131
ENST00000531951
ENST00000528320
ENST00000529999 ENSP00000434863
ENST00000528999
ENST00000531897 ENSP00000437309
ENST00000529693
ENST00000533162 ENSP00000433403
ENST00000527584
ENST00000531995
ENST00000532127
ENST00000526151
ENST00000533362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
Experimentally validated
Total 113 [view]
Protein-Protein 112 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006915 apoptotic process
GO:0008380 RNA splicing
Cellular Component
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSLP pathway
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521924
RefSeq NM_001136033 NM_001271096 NM_001271097 NM_001271098 NM_001271099 NM_001271100 NM_014281 NM_078480
HUGO
OMIM
CCDS CCDS47933 CCDS47934 CCDS47935 CCDS59514 CCDS59515 CCDS59516
HPRD 18051
IMGT
EMBL
GenPept
RNA Seq Atlas