Version 5.4
Homo sapiens Gene: DGKA
Summary
InnateDB Gene IDBG-39397.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGKA
Gene Name diacylglycerol kinase, alpha 80kDa
Synonyms DAGK; DAGK1; DGK-alpha
Species Homo sapiens
Ensembl Gene ENSG00000065357
Encoded Proteins
IDBP-39399
diacylglycerol kinase, alpha 80kDa
IDBP-242140
diacylglycerol kinase, alpha 80kDa
IDBP-295440
diacylglycerol kinase, alpha 80kDa
IDBP-377409
diacylglycerol kinase, alpha 80kDa
IDBP-593023
diacylglycerol kinase, alpha 80kDa
IDBP-591197
diacylglycerol kinase, alpha 80kDa
IDBP-600712
diacylglycerol kinase, alpha 80kDa
IDBP-600631
diacylglycerol kinase, alpha 80kDa
IDBP-596588
diacylglycerol kinase, alpha 80kDa
IDBP-598438
diacylglycerol kinase, alpha 80kDa
IDBP-586316
diacylglycerol kinase, alpha 80kDa
IDBP-586654
diacylglycerol kinase, alpha 80kDa
IDBP-593120
diacylglycerol kinase, alpha 80kDa
IDBP-603219
diacylglycerol kinase, alpha 80kDa
IDBP-593401
diacylglycerol kinase, alpha 80kDa
IDBP-593035
diacylglycerol kinase, alpha 80kDa
IDBP-585206
diacylglycerol kinase, alpha 80kDa
IDBP-599596
diacylglycerol kinase, alpha 80kDa
IDBP-587124
diacylglycerol kinase, alpha 80kDa
IDBP-587325
diacylglycerol kinase, alpha 80kDa
IDBP-602059
diacylglycerol kinase, alpha 80kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:55927319-55954027
Strand Forward strand
Band q13.2
Transcripts
ENST00000331886 ENSP00000328405
ENST00000394147 ENSP00000377703
ENST00000402956 ENSP00000385792
ENST00000432422 ENSP00000402307
ENST00000546878 ENSP00000446515
ENST00000546995
ENST00000547015 ENSP00000449178
ENST00000555090 ENSP00000452353
ENST00000549629 ENSP00000450977
ENST00000555218 ENSP00000451743
ENST00000548479
ENST00000547324
ENST00000553084 ENSP00000446605
ENST00000547358
ENST00000548549 ENSP00000448565
ENST00000549368 ENSP00000447050
ENST00000548407
ENST00000554434
ENST00000555025 ENSP00000450608
ENST00000551615
ENST00000547535
ENST00000549323
ENST00000549097
ENST00000551156 ENSP00000450359
ENST00000553783 ENSP00000450999
ENST00000557080 ENSP00000451814
ENST00000556001 ENSP00000451266
ENST00000550115
ENST00000548378
ENST00000551296
ENST00000551707 ENSP00000447460
ENST00000552478
ENST00000550888 ENSP00000449923
ENST00000549079
ENST00000556344
ENST00000551739
ENST00000549085
ENST00000552687
ENST00000546895
ENST00000549986
ENST00000552335
ENST00000548047
ENST00000557180 ENSP00000451330
ENST00000552652
ENST00000550484
ENST00000552903 ENSP00000451518
ENST00000551585
ENST00000550957
ENST00000548491
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0030168 platelet activation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025357
View Gene Order
ENSBTAG00000004018
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL F8VWX8 G3V4I3
UniProt Splice Variant
Entrez Gene 1606
UniGene Hs.524488 Hs.595019
RefSeq NM_001345 NM_201444 NM_201445 NM_201554 XM_005268688 XM_006719260
HUGO HGNC:2849
OMIM 125855
CCDS CCDS8896
HPRD 00517
IMGT
EMBL AC025162
GenPept
RNA Seq Atlas 1606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca