Version 5.4
Homo sapiens Gene: MEF2BNB-MEF2B
Summary
InnateDB Gene IDBG-39490.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEF2BNB-MEF2B
Gene Name MEF2BNB-MEF2B readthrough
Synonyms LOC729991-MEF2B; MEF2B
Species Homo sapiens
Ensembl Gene ENSG00000064489
Encoded Proteins
IDBP-763539
IDBP-760598
IDBP-810924
MEF2BNB-MEF2B readthrough
IDBP-810928
MEF2BNB-MEF2B readthrough
IDBP-810930
MEF2BNB-MEF2B readthrough
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19145567-19192158
Strand Reverse strand
Band p13.11
Transcripts
ENST00000354191 ENSP00000457957
ENST00000514819 ENSP00000454967
ENST00000602804 ENSP00000473577
ENST00000602276
ENST00000602438
ENST00000602689 ENSP00000473369
ENST00000602424 ENSP00000473308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042826 histone deacetylase binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0030054 cell junction
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005919
HUGO
OMIM
CCDS CCDS12394 CCDS46025
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca