|Homo sapiens Gene: LEP|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Synonyms||LEPD; OB; OBS;|
|Useful resources||Stemformatics EHFPI ImmGen|
LEP upregulates TLR2 expression in monocytes, and may potentiate innate immunity and inflammation in hyperleptinemia conditions, such as obesity and type 2 diabetes mellitus.
LEP (leptin) upregulates TLR2 in human monocytes.
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 7:128241284-128257628|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Developmental Biology pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Signal Transduction pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
Transcriptional regulation of white adipocyte differentiation pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Peptide hormone metabolism pathway
Signaling by Leptin pathway
Cytokine-cytokine receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
Jak-STAT signaling pathway pathway
Adipocytokine signaling pathway pathway
GPCR signaling pathway
Signaling events mediated by PTP1B
HIF-1-alpha transcription factor network
|UniProt Splice Variant|
|RNA Seq Atlas|