Homo sapiens Gene: LEP
InnateDB Gene IDBG-39587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEP
Gene Name leptin
Synonyms LEPD; OB; OBS;
Species Homo sapiens
Ensembl Gene ENSG00000174697
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
LEP upregulates TLR2 expression in monocytes, and may potentiate innate immunity and inflammation in hyperleptinemia conditions, such as obesity and type 2 diabetes mellitus.
LEP (leptin) upregulates TLR2 in human monocytes.
Entrez Gene
Summary This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128241284-128257628
Strand Forward strand
Band q32.1
ENST00000308868 ENSP00000312652
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001542 ovulation from ovarian follicle
GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0001890 placenta development
GO:0001932 regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0006006 glucose metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007165 signal transduction
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0008343 adult feeding behavior
GO:0009062 fatty acid catabolic process
GO:0009892 negative regulation of metabolic process
GO:0019222 regulation of metabolic process
GO:0021954 central nervous system neuron development
GO:0030073 insulin secretion
GO:0030300 regulation of intestinal cholesterol absorption
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0033197 response to vitamin E
GO:0033210 leptin-mediated signaling pathway
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0035630 bone mineralization involved in bone maturation
GO:0042307 positive regulation of protein import into nucleus
GO:0042445 hormone metabolic process
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043066 negative regulation of apoptotic process
GO:0043270 positive regulation of ion transport
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045598 regulation of fat cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045906 negative regulation of vasoconstriction
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0048639 positive regulation of developmental growth
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050901 leukocyte tethering or rolling
GO:0060587 regulation of lipoprotein lipid oxidation
GO:0060612 adipose tissue development
GO:0061037 negative regulation of cartilage development
GO:0070093 negative regulation of glucagon secretion
GO:0071298 cellular response to L-ascorbic acid
GO:0071300 cellular response to retinoic acid
GO:2000366 positive regulation of STAT protein import into nucleus
GO:2000486 negative regulation of glutamine transport
GO:2000491 positive regulation of hepatic stellate cell activation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Leptin pathway
TSH pathway
Developmental Biology pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Signal Transduction pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
Transcriptional regulation of white adipocyte differentiation pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Peptide hormone metabolism pathway
Signaling by Leptin pathway
Cytokine-cytokine receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
Jak-STAT signaling pathway pathway
Adipocytokine signaling pathway pathway
GPCR signaling pathway
Reversal of insulin resistance by leptin [Biocarta view]
Signaling events mediated by PTP1B
HIF-1-alpha transcription factor network
UniProt Splice Variant
Entrez Gene
UniGene Hs.194236
RefSeq NM_000230 XM_005250340
HPRD 01249
RNA Seq Atlas