Homo sapiens Gene: NCAN
Summary
InnateDB Gene IDBG-39616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCAN
Gene Name neurocan
Synonyms CSPG3;
Species Homo sapiens
Ensembl Gene ENSG00000130287
Encoded Proteins
neurocan
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:19211973-19252233
Strand Forward strand
Band p13.11
Transcripts
ENST00000252575 ENSP00000252575
ENST00000590187
ENST00000585410
ENST00000588231 ENSP00000465599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0051823 regulation of synapse structural plasticity
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0043202 lysosomal lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Extracellular matrix organization pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
CS/DS degradation pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
NCAM signaling for neurite out-growth pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Chondroitin sulfate biosynthesis pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
NCAM1 interactions pathway
Axon guidance pathway
Defective SLC26A2 causes chondrodysplasias pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
ECM proteoglycans pathway
Defective B3GAT3 causes JDSSDHD pathway
Dermatan sulfate biosynthesis pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
L1CAM interactions pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Syndecan-3-mediated signaling events
Cross-References
SwissProt O14594
TrEMBL A0A024R7M3 F5H7X3 Q4LE67
UniProt Splice Variant
Entrez Gene 1463
UniGene Hs.169047
RefSeq NM_004386 XM_005259745 XM_005259746
HUGO HGNC:2465
OMIM 600826
CCDS CCDS12397
HPRD
IMGT
EMBL AB210004 AC003110 AC005254 AC138430 AF026547 CH471106
GenPept AAB86655 AAC25581 AAC80576 BAE06086 EAW84801 EAW84802
RNA Seq Atlas 1463