Version 5.4
Homo sapiens Gene: RBM28
Summary
InnateDB Gene IDBG-39628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBM28
Gene Name RNA binding motif protein 28
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106344
Encoded Proteins
IDBP-39630
RNA binding motif protein 28
IDBP-386078
RNA binding motif protein 28
IDBP-482854
RNA binding motif protein 28
IDBP-483105
RNA binding motif protein 28
IDBP-481821
RNA binding motif protein 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128297685-128343908
Strand Reverse strand
Band q32.1
Transcripts
ENST00000223073 ENSP00000223073
ENST00000415472 ENSP00000390517
ENST00000481788
ENST00000495327
ENST00000487602 ENSP00000419840
ENST00000478061 ENSP00000418071
ENST00000488249
ENST00000459726 ENSP00000420503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029701
View Gene Order
ENSBTAG00000017001
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 55131
UniGene Hs.274263
RefSeq NM_001166135 NM_018077
HUGO HGNC:21863
OMIM 612074
CCDS CCDS55159 CCDS5801
HPRD 07668
IMGT
EMBL
GenPept
RNA Seq Atlas 55131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca