Version 5.4
Homo sapiens Gene: FUK
Summary
InnateDB Gene IDBG-40077.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUK
Gene Name fucokinase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157353
Encoded Proteins
IDBP-40079
fucokinase
IDBP-40081
fucokinase
IDBP-750307
IDBP-754557
IDBP-753489
IDBP-753275
IDBP-751143
IDBP-754030
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70454421-70480274
Strand Forward strand
Band q22.1
Transcripts
ENST00000378912 ENSP00000368192
ENST00000288078 ENSP00000288078
ENST00000464499
ENST00000498702 ENSP00000463088
ENST00000485034
ENST00000571514 ENSP00000462584
ENST00000573352 ENSP00000460484
ENST00000576107
ENST00000573832
ENST00000576453 ENSP00000458622
ENST00000572784 ENSP00000458483
ENST00000574784 ENSP00000459168
ENST00000571487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0050201 fucokinase activity
Biological Process
GO:0008152 metabolic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033703
View Gene Order
ENSBTAG00000012985
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.7907
RefSeq NM_145059 XM_006721161 XM_006721163
HUGO
OMIM
CCDS CCDS10891
HPRD 16365
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca