Version 5.4
Homo sapiens Gene: TKT
Summary
InnateDB Gene IDBG-40133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TKT
Gene Name transketolase
Synonyms HEL107; TK; TKT1
Species Homo sapiens
Ensembl Gene ENSG00000163931
Encoded Proteins
IDBP-40135
transketolase
IDBP-379878
transketolase
IDBP-379879
transketolase
IDBP-379883
transketolase
IDBP-473549
transketolase
IDBP-484469
transketolase
IDBP-483433
transketolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:53224707-53256052
Strand Reverse strand
Band p21.1
Transcripts
ENST00000296289 ENSP00000296289
ENST00000423525 ENSP00000405455
ENST00000450814 ENSP00000413503
ENST00000423516 ENSP00000391481
ENST00000462138 ENSP00000417773
ENST00000460343
ENST00000461139
ENST00000469678 ENSP00000418340
ENST00000460243
ENST00000472528 ENSP00000417312
ENST00000494523
ENST00000466765
ENST00000487660
ENST00000483706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004802 transketolase activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048037 cofactor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005999 xylulose biosynthetic process
GO:0006098 pentose-phosphate shunt
GO:0006112 energy reserve metabolic process
GO:0008152 metabolic process
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0040008 regulation of growth
GO:0044281 small molecule metabolic process
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021957
View Gene Order
ENSBTAG00000003758
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_1859
Pentose phosphate pathway (hexose monophosphate shunt) pathway
REACT_939
Insulin effects increased synthesis of Xylulose-5-Phosphate pathway
REACT_1505
Integration of energy metabolism pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00030
Pentose phosphate pathway pathway
INOH
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL F8W888
UniProt Splice Variant
Entrez Gene 7086
UniGene Hs.602713 Hs.89643
RefSeq NM_001064 NM_001135055 NM_001258028
HUGO HGNC:11834
OMIM 606781
CCDS CCDS2871 CCDS58834
HPRD 06001
IMGT
EMBL AC097015
GenPept
RNA Seq Atlas 7086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca