InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAG1

Summary

InnateDB Gene

IDBG-40149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAG1

Gene Name

recombination activating gene 1

Synonyms

RAG-1; RNF74

Species

Homo sapiens

Ensembl Gene

ENSG00000166349

Encoded Proteins

IDBP-40151

recombination activating gene 1

IDBP-600716

recombination activating gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21746813

Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21746813

[Mus musculus] Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response.

Entrez Gene

Summary

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:36510709-36593156

Strand

Forward strand

Band

p12

Transcripts

ENST00000299440	ENSP00000299440
ENST00000529126
ENST00000534663	ENSP00000434610

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004519	endonuclease activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016881	acid-amino acid ligase activity
GO:0042393	histone binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0002250	adaptive immune response
GO:0002331	pre-B cell allelic exclusion
GO:0006310	DNA recombination
GO:0006955	immune response
GO:0010390	histone monoubiquitination
GO:0016265	death
GO:0030183	B cell differentiation
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0043029	T cell homeostasis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045580	regulation of T cell differentiation
GO:0048538	thymus development
GO:0051865	protein autoubiquitination
GO:0070233	negative regulation of T cell apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000061311

View Gene Order

ENSBTAG00000040293

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.677010 Hs.714925 Hs.73958

RefSeq

NM_000448 XM_005253041

HUGO

OMIM

CCDS

CCDS7902

HPRD

01556

IMGT

EMBL

GenPept

RNA Seq Atlas