InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5O

Summary

InnateDB Gene

IDBG-401918.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5O

Gene Name

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Synonyms

ATPO; OSCP

Species

Homo sapiens

Ensembl Gene

ENSG00000241837

Encoded Proteins

IDBP-2638

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

IDBP-363247

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

IDBP-363251

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

IDBP-363256

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

IDBP-363259

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:33903453-33915980

Strand

Reverse strand

Band

q22.11

Transcripts

ENST00000290299	ENSP00000290299
ENST00000431254	ENSP00000393496
ENST00000418933	ENSP00000393211
ENST00000417181	ENSP00000407220
ENST00000429064	ENSP00000403964
ENST00000491703
ENST00000495005
ENST00000496044
ENST00000484627
ENST00000487374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008144	drug binding
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006200	ATP catabolic process
GO:0006754	ATP biosynthetic process
GO:0015986	ATP synthesis coupled proton transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022956

View Gene Order

ENSBTAG00000018278

Not yet available

Pathways

NETPATH

REACTOME

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001697

HUGO

OMIM

CCDS

CCDS13634

HPRD

02899

IMGT

EMBL

GenPept

RNA Seq Atlas