Homo sapiens Gene: PISD
Summary
InnateDB Gene IDBG-402136.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PISD
Gene Name phosphatidylserine decarboxylase
Synonyms DJ858B16; dJ858B16.2; PSD; PSDC; PSSC;
Species Homo sapiens
Ensembl Gene ENSG00000241878
Encoded Proteins
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31618491-31662432
Strand Reverse strand
Band q12.2
Transcripts
ENST00000266095 ENSP00000266095
ENST00000382151 ENSP00000371586
ENST00000397500 ENSP00000380637
ENST00000437808 ENSP00000396500
ENST00000435900 ENSP00000414395
ENST00000439502 ENSP00000391739
ENST00000422020 ENSP00000412169
ENST00000442379 ENSP00000399818
ENST00000429683 ENSP00000396002
ENST00000431201 ENSP00000401606
ENST00000460723
ENST00000473770
ENST00000474017
ENST00000478893
ENST00000491342
ENST00000486675
ENST00000479851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004609 phosphatidylserine decarboxylase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Synthesis of PE pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.420559 Hs.682306
RefSeq NM_014338 XM_005261455 XM_005261456 XM_005261457 XM_005261458 XM_005261459 XM_005261460 XM_005261461 XM_006724200 XM_006724201 XM_006724202
HUGO
OMIM
CCDS CCDS13899
HPRD 17854
IMGT
EMBL
GenPept
RNA Seq Atlas