Version 5.4
| Homo sapiens Gene: PISD | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-402136.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PISD | ||||||||||||||||||
| Gene Name | phosphatidylserine decarboxylase | ||||||||||||||||||
| Synonyms | DJ858B16; dJ858B16.2; PSD; PSDC; PSSC | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000241878 | ||||||||||||||||||
| Encoded Proteins |
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:31618491-31662432 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q12.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Synthesis of PE pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Metabolism pathway
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| KEGG |
Glycerophospholipid metabolism pathway
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| INOH |
Glycine Serine metabolism pathway
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| PID NCI |
FOXA1 transcription factor network
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.420559 Hs.682306 | ||||||||||||||||||
| RefSeq | NM_014338 XM_005261455 XM_005261456 XM_005261457 XM_005261458 XM_005261459 XM_005261460 XM_005261461 XM_006724200 XM_006724201 XM_006724202 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS13899 | ||||||||||||||||||
| HPRD | 17854 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||