Version 5.4
Homo sapiens Gene: RNF41
Summary
InnateDB Gene IDBG-40313.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF41
Gene Name ring finger protein 41
Synonyms FLRF; NRDP1
Species Homo sapiens
Ensembl Gene ENSG00000181852
Encoded Proteins
IDBP-40315
ring finger protein 41
IDBP-242449
ring finger protein 41
IDBP-596548
ring finger protein 41
IDBP-594443
ring finger protein 41
IDBP-588075
ring finger protein 41
IDBP-592157
ring finger protein 41
IDBP-583660
ring finger protein 41
IDBP-584832
ring finger protein 41
IDBP-813391
ring finger protein 41, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19483718
RNF41 is an E3 ligase that can negatively regulate MyD88-dependent production of pro-inflammatory cytokines but can promote TRIF-dependent production of type I interferon.
Entrez Gene
Summary This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56202175-56221933
Strand Reverse strand
Band q13.3
Transcripts
ENST00000345093 ENSP00000342755
ENST00000394013 ENSP00000377581
ENST00000547967 ENSP00000449575
ENST00000552656 ENSP00000447303
ENST00000548120
ENST00000551711 ENSP00000450164
ENST00000552244 ENSP00000448187
ENST00000549038 ENSP00000446595
ENST00000549119 ENSP00000448330
ENST00000548225
ENST00000550379
ENST00000615206 ENSP00000484671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005128 erythropoietin receptor binding
GO:0005135 interleukin-3 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016881 acid-amino acid ligase activity
GO:0031386 protein tag
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030336 negative regulation of cell migration
GO:0043408 regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045619 regulation of lymphocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865 protein autoubiquitination
GO:0051896 regulation of protein kinase B signaling
GO:0097191 extrinsic apoptotic signaling pathway
GO:2000114 regulation of establishment of cell polarity
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025373
View Gene Order
ENSBTAG00000026754
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_115662
Downregulation of ERBB2:ERBB3 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524502 Hs.731431
RefSeq NM_001242826 NM_005785 NM_194358 NM_194359 XM_005268561
HUGO
OMIM
CCDS CCDS8909 CCDS8910
HPRD 11520
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca