Version 5.4
Homo sapiens Gene: IL34
Summary
InnateDB Gene IDBG-40332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL34
Gene Name interleukin 34
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157368
Encoded Proteins
IDBP-40334
interleukin 34
IDBP-380202
interleukin 34
IDBP-751770
IDBP-753385
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70579895-70660682
Strand Forward strand
Band q22.1
Transcripts
ENST00000288098 ENSP00000288098
ENST00000429149 ENSP00000397863
ENST00000569641
ENST00000574181
ENST00000566361 ENSP00000463886
ENST00000563721 ENSP00000455240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006954 inflammatory response
GO:0008284 positive regulation of cell proliferation
GO:0045087 innate immune response
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031750
View Gene Order
ENSBTAG00000009357
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.461214
RefSeq NM_001172771 NM_001172772 NM_152456
HUGO
OMIM
CCDS CCDS10895
HPRD 14582
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca