Version 5.4
Homo sapiens Gene: H2AFJ
Summary
InnateDB Gene IDBG-404621.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2AFJ
Gene Name H2A histone family, member J
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000246705
Encoded Proteins
IDBP-21147
H2A histone family, member J
IDBP-597363
H2A histone family, member J
IDBP-588456
H2A histone family, member J
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14774383-14778002
Strand Forward strand
Band p12.3
Transcripts
ENST00000389078 ENSP00000373730
ENST00000501744 ENSP00000440902
ENST00000544848 ENSP00000438553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005622 intracellular
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt Q9BTM1
TrEMBL A0A024RAS2 H0YFX9 V9GZN0
UniProt Splice Variant
Entrez Gene 55766
UniGene Hs.524280 Hs.613811 Hs.704211
RefSeq NM_177925
HUGO HGNC:14456
OMIM
CCDS CCDS31752
HPRD 13622
IMGT
EMBL AC010168 AK001765 BC003602 CH471094 K01889
GenPept AAA35945 AAH03602 BAA91894 EAW96326 EAW96327
RNA Seq Atlas 55766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca