Version 5.4
Homo sapiens Gene: RAPGEF6
Summary
InnateDB Gene IDBG-40464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAPGEF6
Gene Name Rap guanine nucleotide exchange factor (GEF) 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158987
Encoded Proteins
IDBP-40468
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-40472
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-40474
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-481967
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-484918
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-484984
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-475912
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-484256
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-481791
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-483557
Rap guanine nucleotide exchange factor (GEF) 6
IDBP-473809
Rap guanine nucleotide exchange factor (GEF) 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:131423921-131635236
Strand Reverse strand
Band q31.1
Transcripts
ENST00000296859 ENSP00000296859
ENST00000307984 ENSP00000309298
ENST00000308008 ENSP00000311419
ENST00000509018 ENSP00000421684
ENST00000512611
ENST00000507093 ENSP00000426081
ENST00000512052 ENSP00000426910
ENST00000515170 ENSP00000425772
ENST00000510071 ENSP00000425389
ENST00000504919
ENST00000514179
ENST00000513227 ENSP00000424574
ENST00000504575 ENSP00000425891
ENST00000504039 ENSP00000427102
ENST00000503398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037533
View Gene Order
ENSBTAG00000000682
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.483329
RefSeq NM_001164386 NM_001164387 NM_001164388 NM_001164389 NM_001164390 NM_016340
HUGO
OMIM
CCDS CCDS34225 CCDS54897 CCDS54898 CCDS54899 CCDS54900
HPRD 11483
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca