Homo sapiens Gene: FBXL6
Summary
InnateDB Gene IDBG-40677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL6
Gene Name F-box and leucine-rich repeat protein 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182325
Encoded Proteins
F-box and leucine-rich repeat protein 6
F-box and leucine-rich repeat protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144355431-144359376
Strand Reverse strand
Band q24.3
Transcripts
ENST00000331890 ENSP00000330098
ENST00000455319 ENSP00000403873
ENST00000524492
ENST00000530142
ENST00000526524
ENST00000527000
ENST00000524909
ENST00000529279
ENST00000530687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8N531
TrEMBL
UniProt Splice Variant
Entrez Gene 26233
UniGene Hs.12271
RefSeq NM_024555 NM_012162
HUGO HGNC:13603
OMIM 609076
CCDS CCDS47942 CCDS6422
HPRD 16429
IMGT
EMBL AF174592 AK026541 AK223088 BC033066
GenPept AAF04513 AAH33066 BAB15499 BAD96808
RNA Seq Atlas 26233