Homo sapiens Gene: FBXL6
Summary
InnateDB Gene IDBG-40677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL6
Gene Name F-box and leucine-rich repeat protein 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182325
Encoded Proteins
F-box and leucine-rich repeat protein 6
F-box and leucine-rich repeat protein 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144355431-144359376
Strand Reverse strand
Band q24.3
Transcripts
ENST00000331890 ENSP00000330098
ENST00000455319 ENSP00000403873
ENST00000524492
ENST00000530142
ENST00000526524
ENST00000527000
ENST00000524909
ENST00000529279
ENST00000530687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12271
RefSeq NM_012162 NM_024555
HUGO
OMIM
CCDS CCDS47942 CCDS6422
HPRD 16429
IMGT
EMBL
GenPept
RNA Seq Atlas