Homo sapiens Gene: TICAM2
Summary
InnateDB Gene IDBG-406966.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TICAM2
Gene Name toll-like receptor adaptor molecule 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000243414
Encoded Proteins
toll-like receptor adaptor molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TICAM2 deficiency results in the impairment of LPS-stimulated TNF-alpha protein translation. (Demonstrated in murine model)
ARF6 regulates LPS internalization and LPS-induced relocation of TICAM2 (TRAM), which is required for the MyD88-independent TLR4 signalling cascade.
The homotypic interaction of TICAM2 Toll/interleukin-1 receptor (TIR) domain is essential to form a scaffold for recruiting the TICAM1 TIR domain.
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115578650-115602479
Strand Reverse strand
Band q22.3
Transcripts
ENST00000427199 ENSP00000415139
ENST00000513729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0070671 response to interleukin-12
GO:0071222 cellular response to lipopolysaccharide
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:2000494 positive regulation of interleukin-18-mediated signaling pathway
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated programmed cell death pathway
Innate Immune System pathway
IKK complex recruitment mediated by RIP1 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated induction of TAK1 complex pathway
Immune System pathway
MyD88-independent cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
Toll-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
IL1-mediated signaling events
Cross-References
SwissProt Q86XR7
TrEMBL
UniProt Splice Variant
Entrez Gene 353376
UniGene Hs.611673 Hs.738624
RefSeq NM_021649
HUGO HGNC:21354
OMIM 608321
CCDS CCDS4119
HPRD 16313
IMGT
EMBL AB091054 AB097022 AB109098 AB446491 AC010226 AY232653 AY275836 AY304581 AY304582 AY304583 AY304584 BC109265 BC109266 CH471086
GenPept AAI09266 AAI09267 AAO74498 AAP81748 AAQ97430 AAQ97431 AAQ97432 AAQ97433 BAC77375 BAC98397 BAC98399 BAG55268 EAW48960 EAW48961
RNA Seq Atlas 353376