Homo sapiens Gene: CCL13
Summary
InnateDB Gene IDBG-40707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL13
Gene Name chemokine (C-C motif) ligand 13
Synonyms CKb10; MCP-4; NCC-1; NCC1; SCYA13; SCYL1;
Species Homo sapiens
Ensembl Gene ENSG00000181374
Encoded Proteins
chemokine (C-C motif) ligand 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34356452-34358610
Strand Forward strand
Band q12
Transcripts
ENST00000225844 ENSP00000225844
ENST00000577681 ENSP00000463667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008009 chemokine activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008360 regulation of cell shape
GO:0048245 eosinophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99616
TrEMBL
UniProt Splice Variant
Entrez Gene 6357
UniGene Hs.414629
RefSeq NM_005408
HUGO HGNC:10611
OMIM 601391
CCDS CCDS11281
HPRD 03230
IMGT
EMBL AC002482 AJ001634 BC008621 BT007385 CH471147 CR450337 U46767 U59808 X98306 Z77650
GenPept AAB38703 AAB67307 AAD09362 AAH08621 AAP36049 CAA04888 CAA66950 CAB01111 CAG29333 EAW80206
RNA Seq Atlas 6357