Version 5.4
| Homo sapiens Gene: MRPL33 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-407246.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | MRPL33 | ||||||||||||||||||
| Gene Name | mitochondrial ribosomal protein L33 | ||||||||||||||||||
| Synonyms | C2orf1; L33mt; MRP-L33; RPL33L | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000243147 | ||||||||||||||||||
| Encoded Proteins |
mitochondrial ribosomal protein L33
mitochondrial ribosomal protein L33
mitochondrial ribosomal protein L33
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 2:27771717-27988087 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p23.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
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| KEGG |
Ribosome pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O75394 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 9553 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_004891 NM_145330 | ||||||||||||||||||
| HUGO | HGNC:14487 | ||||||||||||||||||
| OMIM | 610059 | ||||||||||||||||||
| CCDS | CCDS1761 CCDS33167 | ||||||||||||||||||
| HPRD | 14753 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB051623 AC021171 AC074091 AC110084 AF047440 BC009475 BC020834 BC090047 CH471053 CR456888 CR542117 | ||||||||||||||||||
| GenPept | AAC39891 AAH09475 AAH20834 AAH90047 AAX93204 BAB54951 CAG33169 CAG46914 EAX00552 | ||||||||||||||||||
| RNA Seq Atlas | 9553 | ||||||||||||||||||