Homo sapiens Gene: MRPL33
Summary
InnateDB Gene IDBG-407246.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL33
Gene Name mitochondrial ribosomal protein L33
Synonyms C2orf1; L33mt; MRP-L33; RPL33L;
Species Homo sapiens
Ensembl Gene ENSG00000243147
Encoded Proteins
mitochondrial ribosomal protein L33
mitochondrial ribosomal protein L33
mitochondrial ribosomal protein L33
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27771717-27988087
Strand Forward strand
Band p23.2
Transcripts
ENST00000296102 ENSP00000296102
ENST00000379666 ENSP00000368988
ENST00000448427 ENSP00000407385
ENST00000472192
ENST00000483992
ENST00000476552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75394
TrEMBL
UniProt Splice Variant
Entrez Gene 9553
UniGene
RefSeq NM_145330 NM_004891
HUGO HGNC:14487
OMIM 610059
CCDS CCDS33167 CCDS1761
HPRD 14753
IMGT
EMBL AB051623 AC021171 AC074091 AC110084 AF047440 BC009475 BC020834 BC090047 CH471053 CR456888 CR542117
GenPept AAC39891 AAH09475 AAH20834 AAH90047 AAX93204 BAB54951 CAG33169 CAG46914 EAX00552
RNA Seq Atlas 9553