Homo sapiens Gene: CPSF1
Summary
InnateDB Gene IDBG-40804.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF1
Gene Name cleavage and polyadenylation specific factor 1, 160kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000071894
Encoded Proteins
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specific factor 1, 160kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144393229-144409349
Strand Reverse strand
Band q24.3
Transcripts
ENST00000531480
ENST00000531727 ENSP00000483775
ENST00000532725
ENST00000526271
ENST00000532935 ENSP00000478161
ENST00000529288
ENST00000527827
ENST00000527916
ENST00000533492
ENST00000532560
ENST00000531042 ENSP00000435761
ENST00000620219 ENSP00000478145
ENST00000622776
ENST00000616140 ENSP00000484669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 55 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
mRNA 3'-end processing pathway
RNA Polymerase II Transcription Termination pathway
Transport of Mature mRNA Derived from an Intronless Transcript pathway
Processing of Intronless Pre-mRNAs pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
Processing of Capped Intronless Pre-mRNA pathway
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
Polyadenylation of mrna [Biocarta view]
PID NCI
Cross-References
SwissProt Q10570
TrEMBL D3DWL9 E9PIM1 Q9C0J6
UniProt Splice Variant
Entrez Gene 29894
UniGene
RefSeq NM_013291 XM_006716548 XM_006716549 XM_006716550
HUGO HGNC:2324
OMIM 606027
CCDS CCDS34966
HPRD
IMGT
EMBL AB046744 AF205589 BC017232 CH471162 U37012
GenPept AAC50293 AAH17232 BAB21613 EAW82106 EAW82107 EAW82108
RNA Seq Atlas 100126351 100302196 102466749 29894