Version 5.4
Homo sapiens Gene: TNFSF12
Summary
InnateDB Gene IDBG-408330.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF12
Gene Name tumor necrosis factor (ligand) superfamily, member 12
Synonyms APO3L; DR3LG; TWEAK
Species Homo sapiens
Ensembl Gene ENSG00000239697
Encoded Proteins
IDBP-25392
tumor necrosis factor (ligand) superfamily, member 12
IDBP-25394
tumor necrosis factor (ligand) superfamily, member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7548891-7557890
Strand Forward strand
Band p13.1
Transcripts
ENST00000293825 ENSP00000293825
ENST00000322272 ENSP00000314636
ENST00000462619
ENST00000462811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0030154 cell differentiation
GO:0043542 endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0097190 apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_26
TWEAK pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt O43508
TrEMBL Q4ACW9
UniProt Splice Variant
Entrez Gene 8742
UniGene
RefSeq NM_003809
HUGO HGNC:11927
OMIM 602695
CCDS CCDS11109
HPRD 04074
IMGT
EMBL AB222993 AC016876 AF030099 AF055872 AY081051 AY358870 BC019047 BC104420 CH471108
GenPept AAC39724 AAC51923 AAH19047 AAI04421 AAL90443 AAQ89229 BAE16557 EAW90179
RNA Seq Atlas 8742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca