InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKDC

Summary

InnateDB Gene

IDBG-408612.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKDC

Gene Name

protein kinase, DNA-activated, catalytic polypeptide

Synonyms

DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7

Species

Homo sapiens

Ensembl Gene

ENSG00000253729

Encoded Proteins

IDBP-20942

protein kinase, DNA-activated, catalytic polypeptide

IDBP-20944

protein kinase, DNA-activated, catalytic polypeptide

IDBP-596793

protein kinase, DNA-activated, catalytic polypeptide

IDBP-598311

protein kinase, DNA-activated, catalytic polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24098118

Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblast.

Entrez Gene

Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:47773108-47960183

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000314191	ENSP00000313420
ENST00000338368	ENSP00000345182
ENST00000432581
ENST00000521331
ENST00000536429	ENSP00000442177
ENST00000536483
ENST00000536710
ENST00000546304
ENST00000541488
ENST00000535375
ENST00000540819	ENSP00000441157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 298 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	298 [view]
Protein-Protein	293 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004677	DNA-dependent protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0001756	somitogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0002326	B cell lineage commitment
GO:0002328	pro-B cell differentiation
GO:0002360	T cell lineage commitment
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007420	brain development
GO:0007507	heart development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332	response to gamma radiation
GO:0018105	peptidyl-serine phosphorylation
GO:0030098	lymphocyte differentiation
GO:0031648	protein destabilization
GO:0032481	positive regulation of type I interferon production
GO:0032869	cellular response to insulin stimulus
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0033153	T cell receptor V(D)J recombination
GO:0035234	ectopic germ cell programmed cell death
GO:0042752	regulation of circadian rhythm
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020	membrane
GO:0070419	nonhomologous end joining complex