Version 5.4
Homo sapiens Gene: PCDHA10
Summary
InnateDB Gene IDBG-408644.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA10
Gene Name protocadherin alpha 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000250120
Encoded Proteins
IDBP-49723
protocadherin alpha 10
IDBP-475886
protocadherin alpha 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140855883-141012344
Strand Forward strand
Band q31.3
Transcripts
ENST00000307360 ENSP00000304234
ENST00000506939 ENSP00000421030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5I2
TrEMBL
UniProt Splice Variant
Entrez Gene 56139
UniGene
RefSeq NM_018901 NM_031859 NM_031860
HUGO HGNC:8664
OMIM 606316
CCDS CCDS34255 CCDS54921 CCDS75325
HPRD
IMGT
EMBL AC005609 AF152306 AF152475 AF169689 BC130447
GenPept AAC34317 AAD43700 AAD43736 AAF89329 AAI30448
RNA Seq Atlas 56139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca