Homo sapiens Gene: PCDHA11
Summary
InnateDB Gene IDBG-408652.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA11
Gene Name protocadherin alpha 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000249158
Encoded Proteins
protocadherin alpha 11
protocadherin alpha 11
protocadherin alpha 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140868183-141012344
Strand Forward strand
Band q31.3
Transcripts
ENST00000398640 ENSP00000381636
ENST00000616325 ENSP00000482503
ENST00000617408 ENSP00000482347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007399 nervous system development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56138
UniGene
RefSeq NM_018902 NM_031861
HUGO HGNC:8665
OMIM 606317
CCDS CCDS47284 CCDS75326
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 56138