Homo sapiens Gene: PCDHA13
Summary
InnateDB Gene IDBG-408690.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHA13
Gene Name protocadherin alpha 13
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000239389
Encoded Proteins
protocadherin alpha 13
protocadherin alpha 13
protocadherin alpha 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140882208-141012344
Strand Forward strand
Band q31.3
Transcripts
ENST00000289272 ENSP00000289272
ENST00000409494 ENSP00000386821
ENST00000617769 ENSP00000479167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5I0
TrEMBL
UniProt Splice Variant
Entrez Gene 56136
UniGene
RefSeq NM_018904 NM_031865
HUGO HGNC:8667
OMIM 606319
CCDS CCDS4240
HPRD 07554
IMGT
EMBL AC005609 AF152309 AF152478
GenPept AAC34314 AAD43703 AAD43739
RNA Seq Atlas 56136