InnateDB Gene
|
IDBG-408690.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PCDHA13
|
Gene Name
|
protocadherin alpha 13
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Gene
|
ENSG00000239389
|
Encoded Proteins
|
|
Protein Structure
|
|
Useful resources
|
Stemformatics
EHFPI
ImmGen
|
Summary |
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
|
Type |
Protein coding
|
Genomic Location
|
Chromosome 5:140882208-141012344
|
Strand
|
Forward strand
|
Band
|
q31.3
|
Transcripts
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
|
No orthologs found for this gene |
SwissProt
|
|
TrEMBL
|
C9JA99
Q59H35
|
UniProt Splice Variant
|
|
Entrez Gene
|
56136
|
UniGene
|
|
RefSeq
|
NM_018904
NM_031865
|
HUGO
|
HGNC:8667
|
OMIM
|
606319
|
CCDS
|
CCDS4240
|
HPRD |
07554
|
IMGT
|
|
EMBL
|
AB208924
AC005609
AC008468
AC010223
|
GenPept
|
BAD92161
|
RNA Seq Atlas
|
56136
|
|
|