Version 5.4
Homo sapiens Gene: UBE2V1
Summary
InnateDB Gene IDBG-408829.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2V1
Gene Name ubiquitin-conjugating enzyme E2 variant 1
Synonyms CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A
Species Homo sapiens
Ensembl Gene ENSG00000244687
Encoded Proteins
IDBP-80708
ubiquitin-conjugating enzyme E2 variant 1
IDBP-80710
ubiquitin-conjugating enzyme E2 variant 1
IDBP-80716
ubiquitin-conjugating enzyme E2 variant 1
IDBP-80720
ubiquitin-conjugating enzyme E2 variant 1
IDBP-378363
ubiquitin-conjugating enzyme E2 variant 1
IDBP-378379
ubiquitin-conjugating enzyme E2 variant 1
IDBP-476731
ubiquitin-conjugating enzyme E2 variant 1
IDBP-810912
ubiquitin-conjugating enzyme E2 variant 1
IDBP-810913
ubiquitin-conjugating enzyme E2 variant 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:50081124-50115959
Strand Reverse strand
Band q13.13
Transcripts
ENST00000371677 ENSP00000360742
ENST00000371674 ENSP00000360739
ENST00000340309 ENSP00000340305
ENST00000371657 ENSP00000360720
ENST00000396059
ENST00000415862 ENSP00000407770
ENST00000420027 ENSP00000395264
ENST00000432266
ENST00000483534 ENSP00000421351
ENST00000486653
ENST00000490555
ENST00000493090
ENST00000467839
ENST00000472923
ENST00000470565
ENST00000490289
ENST00000461960
ENST00000462217
ENST00000473860
ENST00000492371
ENST00000468926
ENST00000625172 ENSP00000485599
ENST00000617119 ENSP00000484828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
Experimentally validated
Total 128 [view]
Protein-Protein 128 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
GO:0031624 ubiquitin conjugating enzyme binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006282 regulation of DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0030154 cell differentiation
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042275 error-free postreplication DNA repair
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031371 ubiquitin conjugating enzyme complex
GO:0035370 UBC13-UEV1A complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_24918
IRAK1 recruits IKK complex pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25120
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_25354
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12555
Downstream TCR signaling pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_12526
TCR signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
PID NCI
il1pathway
IL1-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598128 Hs.605162 Hs.741376
RefSeq NM_001032288 NM_001257393 NM_001257394 NM_001257395 NM_001257396 NM_001257397 NM_001257398 NM_001257399 NM_001282576 NM_001282579 NM_021988 NM_022442 NM_199144
HUGO
OMIM
CCDS CCDS13426 CCDS13427 CCDS33483 CCDS58775 CCDS74740
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca