Version 5.4
Homo sapiens Gene: BGLAP
Summary
InnateDB Gene IDBG-408869.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BGLAP
Gene Name bone gamma-carboxyglutamate (gla) protein
Synonyms BGP; OC; OCN
Species Homo sapiens
Ensembl Gene ENSG00000242252
Encoded Proteins
IDBP-103429
bone gamma-carboxyglutamate (gla) protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156241962-156243321
Strand Forward strand
Band q22
Transcripts
ENST00000368272 ENSP00000357255
ENST00000471413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 1 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0008147 structural constituent of bone
GO:0046848 hydroxyapatite binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0002076 osteoblast development
GO:0007155 cell adhesion
GO:0007568 aging
GO:0007569 cell aging
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0010035 response to inorganic substance
GO:0010043 response to zinc ion
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0030282 bone mineralization
GO:0030500 regulation of bone mineralization
GO:0031667 response to nutrient levels
GO:0032571 response to vitamin K
GO:0033280 response to vitamin D
GO:0033574 response to testosterone
GO:0033594 response to hydroxyisoflavone
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045124 regulation of bone resorption
GO:0045471 response to ethanol
GO:0045670 regulation of osteoclast differentiation
GO:0051384 response to glucocorticoid
GO:0060348 bone development
GO:0071305 cellular response to vitamin D
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0030425 dendrite
GO:0031988 membrane-bounded vesicle
GO:0042995 cell projection
GO:0043204 perikaryon
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
rb_1pathway
Regulation of retinoblastoma protein
hes_heypathway
Notch-mediated HES/HEY network
reg_gr_pathway
Glucocorticoid receptor regulatory network
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt P02818
TrEMBL
UniProt Splice Variant
Entrez Gene 632
UniGene
RefSeq NM_199173
HUGO HGNC:1043
OMIM 112260
CCDS CCDS1134
HPRD
IMGT
EMBL AL135927 BC113432 BC113434 CH471121 DQ007079 X04143 X51699 X53698
GenPept AAI13433 AAI13435 AAY16981 CAA27763 CAA35996 CAA37736 CAI15541 EAW52986
RNA Seq Atlas 632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca