Homo sapiens Gene: IL23A
Summary
InnateDB Gene IDBG-40891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL23A
Gene Name interleukin 23, alpha subunit p19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110944
Encoded Proteins
interleukin 23, alpha subunit p19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL23A expression is regulated by MAP3K8 in lipopolysaccharide (LPS)-stimulated macrophages through ERK activation.
IL23A suppresses innate immune response independently of IL17A during carcinogenesis and metastasis (shown in mice).
IL23A is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. IL23A is transcriptionally inhibited by the binding of IRF1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation (shown in mice).
Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Il23a is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. Il23a is transcriptionally inhibited by the binding of Irf1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation.
Entrez Gene
Summary This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56334174-56340410
Strand Forward strand
Band q13.3
Transcripts
ENST00000228534 ENSP00000228534
ENST00000622119
ENST00000619177
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045519 interleukin-23 receptor binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0032693 negative regulation of interleukin-10 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382 positive regulation of memory T cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048771 tissue remodeling
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070743 interleukin-23 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
ATF-2 transcription factor network
IL23-mediated signaling events
Cross-References
SwissProt Q9NPF7
TrEMBL
UniProt Splice Variant
Entrez Gene 51561
UniGene Hs.98309
RefSeq NM_016584
HUGO HGNC:15488
OMIM 605580
CCDS CCDS8916
HPRD 12026
IMGT
EMBL AB030000 AB030001 AF301620 AY359083 BC066267 BC066268 BC066269 BC067511 BC067512 BC067513
GenPept AAG37232 AAH66267 AAH66268 AAH66269 AAH67511 AAH67512 AAH67513 AAQ89442 BAA93686 BAA93687
RNA Seq Atlas 51561