|Homo sapiens Gene: IL23A|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 23, alpha subunit p19|
interleukin 23, alpha subunit p19
|Useful resources||Stemformatics EHFPI ImmGen|
IL23A expression is regulated by MAP3K8 in lipopolysaccharide (LPS)-stimulated macrophages through ERK activation.
IL23A suppresses innate immune response independently of IL17A during carcinogenesis and metastasis (shown in mice).
IL23A is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. IL23A is transcriptionally inhibited by the binding of IRF1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation (shown in mice).
Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.
|InnateDB Annotation from Orthologs|
[Mus musculus] Il23a is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. Il23a is transcriptionally inhibited by the binding of Irf1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation.
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 12:56334174-56340410|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
ATF-2 transcription factor network
IL23-mediated signaling events
|UniProt Splice Variant|
|EMBL||AB030000 AB030001 AF301620 AY359083 BC066267 BC066268 BC066269 BC067511 BC067512 BC067513|
|GenPept||AAG37232 AAH66267 AAH66268 AAH66269 AAH67511 AAH67512 AAH67513 AAQ89442 BAA93686 BAA93687|
|RNA Seq Atlas||51561|