InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL23A

Summary

InnateDB Gene

IDBG-40891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL23A

Gene Name

interleukin 23, alpha subunit p19

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000110944

Encoded Proteins

IDBP-40893

interleukin 23, alpha subunit p19

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20405269

IL23A expression is regulated by MAP3K8 in lipopolysaccharide (LPS)-stimulated macrophages through ERK activation.

PMID 20404142

IL23A suppresses innate immune response independently of IL17A during carcinogenesis and metastasis (shown in mice).

PMID 21097874

IL23A is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. IL23A is transcriptionally inhibited by the binding of IRF1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation (shown in mice).

PMID 26187413

Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

InnateDB Annotation from Orthologs

Summary

PMID 21097874

[Mus musculus] Il23a is a LPS induced gene, and its expression in macrophages correlate with the severity of chronic intestinal inflammation. Il23a is transcriptionally inhibited by the binding of Irf1 to the ISRE element and serve as a homeostatic checkpoint in chronic intestinal inflammation.

Entrez Gene

Summary

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:56334174-56340410

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000228534	ENSP00000228534
ENST00000622119
ENST00000619177

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0045519	interleukin-23 receptor binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010535	positive regulation of activation of JAK2 kinase activity
GO:0032693	negative regulation of interleukin-10 production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032816	positive regulation of natural killer cell activation
GO:0032819	positive regulation of natural killer cell proliferation
GO:0034105	positive regulation of tissue remodeling
GO:0042098	T cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382	positive regulation of memory T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048771	tissue remodeling
GO:0050729	positive regulation of inflammatory response
GO:0050829	defense response to Gram-negative bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0051142	positive regulation of NK T cell proliferation
GO:0051607	defense response to virus
GO:0090023	positive regulation of neutrophil chemotaxis
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000330	positive regulation of T-helper 17 cell lineage commitment

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070743	interleukin-23 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025383

View Gene Order

ENSBTAG00000004378

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

atf2_pathway

ATF-2 transcription factor network

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_016584

HUGO

OMIM

CCDS

CCDS8916

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas